Tauroursodeoxycholic acid (TUDCA) is an ambiphilic bile acid. It is the taurine conjugate form of ursodeoxycholic acid (TUDCA). Humans are found to have trace amounts of TUDCA. However, bears contain large amounts of TUDCA in their bile; TUDCA and conjugates comprise about 47% of the bile in American black bears and up to 76% in Asiatic bears. TUDCA has been used in ancient Asian pharmacopoeias for its supposed beneficial effects. TUDCA is produced in several countries for the treatment of gallstones and liver cirrhosis. It is not approved by the Food and Drug Administration, in the U.S. while UDCA is approved in the United States for the treatment of primary biliary cirrhosis Ongoing research is finding TUDCA has diminishing apoptotic effects, with potential application in heart disease, Huntington's disease, Parkinson's disease, and stroke. Recently, TUDCA has been found to have protective effects in the eye, especially concerning retinal degenerative disorders.
Tauroursodeoxycholic acid (TUDCA) is a bile acid derivative that has been used in Europe to treat cholelithiasis and cholestatic liver disease. TUDCA can also act as a chemical chaperone to enhance protein folding and protect cells against ER stress (18).
Short-term therapy with TUDCA is effective in lowering serum levels of transaminases and GGT, is free of hepatotoxic effects, and improves dyspeptic symptoms in patients with chronic active hepatitis.
Your liver bile duct can get physically blocked in several ways:
Gallbladder stones can obstruct it and stop your flow of bile
Liver injury can cause scar tissue formation in your bile duct, making the opening much smaller so less bile can get through
Viruses like Hepatitis C can create scar tissue as well as reduce the opening of the duct
A poor diet can make bile thick and sludgy, unable to flow properly
Parasites can physically block the bile duct
Tumors or cysts
Autoimmune disorders or Cystic Fibrosis
Fatty liver disease can cause triglycerides to collect in the bile duct and block it (1)
Certain drugs can chemically alter your bile flow and bile quality. These include:
Diuretics used for hypertension
Blood pressure medication
Anti-anxiety drugs (2)
Medications for Type II Diabetes (3)
What’s The Big Deal About Bile?
TUDCA benefits your liver bile duct and supports your liver. But why is this important?
Not having a free-flowing bile duct causes a domino effect that negatively impacts your health in every area.
Think of your liver like the water processing plant of a city. Water from every pipe and drain in the city merges to a central place. There, it is cleaned of debris and contamination. Clean, purified water then flows back to all the homes and businesses in the city. The contaminated sludge gets hauled away so it doesn’t become a problem and pollute the water again. The cycle keeps repeating to protect people from contaminated water.
Milk thistle is used as a natural remedy to treat a range of health conditions. But are there any proven health benefits of milk thistle?
The active ingredient in milk thistle is called silymarin. Milk thistle is also known as Mary thistle or holy thistle. It is mainly used to treat liver problems, it is claimed it can lower cholesterol and help manage type 2 diabetes.
Milk thistle is a flowering plant that comes from the same family of plants as the daisy. It grows in Mediterranean countries and is used to make natural remedies.
Different parts of the milk thistle plant may be used to treat various health conditions. The most common use of milk thistle is for liver problems.
It can help treat:
Ten health benefits of milk thistle
Supports liver health. One of the most common uses of milk thistle is to treat liver problems.
Promotes skin health.
Supports weight loss.
Reduces insulin resistance.
Improves allergic asthma symptoms.
Limits the spread of cancer.
Supports bone health.
Our recommended dosage for Tudca and Milk Thistle when supplementing is to take one 500 mg capsules per day. Our capsules contain 250mg of Tudca and 250mg Milk Thistle.